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Modulation of cellular ageing regulates Integrated Stress Response signalling to control blood cell homeostasis

2025-01-09

Abstract excerpt

Organismal ageing is associated with a decline in cellular and molecular functions. One of the hallmarks of ageing is stem cell exhaustion which occurs due to dynamic changes in the stem cell – niche microenvironment. Ageing affects stem cell potency impacting self-renewal and differentiation trajectories. Blood cell homeostasis in the hematopoietic system is tightly regulated by a fine balance between stemness an...

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Literature Corpus work
de8f0208-a1b4-55df-9581-5f611aba6d2d
DOI
10.1101/2025.01.09.632127
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Modulation of cellular ageing regulates Integrated Stress Response signalling to control blood cell homeostasisDOI 10.1101/2025.01.09.632127
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