Article

Genetic susceptibility to earlier ovarian ageing increases <i>de novo</i> mutation rate in offspring

2022-06-23

Abstract excerpt

Human genetic studies have provided substantial insight into the biological mechanisms governing ovarian ageing, yet previous approaches have been largely restricted to assessing common genetic variation. Here we report analyses of rare (MAF<0.1%) protein-coding variants in the exomes of 106,973 women from the UK Biobank study, implicating novel genes with effect sizes up to ∼5 times larger than previously discove...

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Literature Corpus work: 0fe9a703-f786-5726-885a-f5232ea7ecab
DOI: 10.1101/2022.06.23.22276698

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