Article

GPN-MSA: an alignment-based DNA language model for genome-wide variant effect prediction

2023-10-11

Abstract excerpt

Whereas protein language models have demonstrated remarkable efficacy in predicting the effects of missense variants, DNA counterparts have not yet achieved a similar competitive edge for genome-wide variant effect predictions, especially in complex genomes such as that of humans. To address this challenge, we here introduce GPN-MSA, a novel framework for DNA language models that leverages whole-genome sequence al...

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Literature Corpus work: de3aeb99-855d-5875-b7dc-1a8afd721c40
DOI: 10.1101/2023.10.10.561776

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