Article

Candidate Explorer: a tool for discovery, evaluation, and display of mutations causing significant immune phenotypes

2020-11-07

Abstract excerpt

When applied to immunity, forward genetic studies use meiotic mapping to provide strong statistical evidence that a particular mutation is causative of a particular immune phenotype. Notwithstanding this, co-segregation of multiple mutations, occasional unawareness of mutations, and paucity of homozygotes may lead to erroneous declarations of cause and effect. We sought to improve the selection of authentic causat...

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Literature Corpus work: de1b8329-d890-5fce-84c1-c33e7c2f2be4
DOI: 10.1101/2020.11.07.371914

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