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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma

2019-01-01

Abstract excerpt

Immunotherapy with checkpoint inhibitors has not been effective thus far in patients with micro-satellite stable pancreatic ductal adenocarcinoma (PDAC), which suggests an immunosuppressive mechanism operates within the tumour microenvironment (TME) of PDAC. In the KRasG12D; p53R172H; Pdx1-Cre (KPC) genetically engineered mouse model of PDAC, T cells are excluded from tumour nests and this effect is related to the...

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Literature Corpus work
dd6f9ea3-dd66-5dcf-96fe-dd614bef2ac1
DOI
10.17863/cam.37722
Open publication

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