Article

Haplotyping by linked-read sequencing (HLRS) of the genetic disease carriers for preimplantation genetic testing without a proband or relatives

2020-03-09

Abstract excerpt

<h4>Background: </h4> In order to mitigate the risk of allele dropout (ADO) and ensure the accuracy of preimplantation genetic testing for monogenic disease (PGT-M), it is necessary to construct parental haplotypes.. Typically, haplotype resolution is obtained by genotyping multiple polymorphic markers in both parents and a proband or a relative. Sometimes, single sperm typing, or tests on the polar bodies may als...

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Literature Corpus work: dd6c7ae5-c279-5726-93d1-c7d4754eb9b4
DOI: 10.21203/rs.3.rs-16325/v1

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