Article

Imputation-powered whole-exome analysis identifies rare coding variants and genes associated with kidney function and disease in the UK Biobank

2022-08-30

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate rare coding variants. Here, we applied a genotype imputation approach to whole exome sequencing data from the UK Biobank to increase sample size from 166,891 to 408,511. We detected 158 rare variants and 105 genes significantly asso...

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Literature Corpus work: dcf282c5-e5c7-5677-8321-a0c380023389
DOI: 10.21203/rs.3.rs-1936427/v1

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