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Article

Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank.

Nature communications - 9 Mar 2023

Wuttke Matthias, König Eva, Katsara Maria-Alexandra, Kirsten Holger, Farahani Saeed Khomeijani, Teumer Alexander, Li Yong, Lang Martin, Göcmen Burulca, Pattaro Cristian, Günzel Dorothee, Köttgen Anna, Fuchsberger Christian

Abstract excerpt

Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate rare coding variants. Here, we apply a genotype imputation approach to whole exome sequencing data from the UK Biobank to increase sample size from 166,891 to 408,511. We detect 158 rare variants and 105 genes significantly associated with one or more of five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36890159
DOI: 10.1038/s41467-023-36864-8
PMCID: PMC9995463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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