Article

Rovaca: A highly optimized variant caller for rapid and robust germline DNA analysis

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> The Genome Analysis Toolkit (GATK) HaplotypeCaller is the gold standard for germline variant detection, but its computational intensity presents a significant bottleneck in large-scale genomic analyses. While accelerated solutions exist, they often require specialized hardware or are proprietary, limiting accessibility. We present Rovaca, a novel, pure software variant caller implemented in C++...

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Literature Corpus work: dcabc6ec-fb0c-58aa-8505-061ce77d3e62
DOI: 10.1101/2025.10.19.677660

Open publication

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