Article

Accelerated and High-Accuracy Variant Calling on Oxford Nanopore Technologies Sequencing Data with the Sentieon DNAscope LongRead and Hybrid Pipelines

2025-11-16

Abstract excerpt

Oxford Nanopore Technologies (ONT) has emerged as a clinically meaningful long-read sequencing platform, enabled by recent improvements in read accuracy and throughput. However, variant calling on ONT data remains challenging due to platform-specific error profiles, particularly indels in homopolymer regions. Here, we introduce description and comprehensive benchmarks of the Sentieon DNAscope LongRead and DNAscope...

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Literature Corpus work: a4504fb3-bf42-5d63-a12f-7e9814da641b
DOI: 10.1101/2025.11.14.688541

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