Article

CHOP-c-JUN complex plays a critical role in liver proteotoxicity induced by mutant Z alpha-1 antitrypsin

2020-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-1 antitrypsin (AAT) deficiency is a common genetic disorder with lung and liver involvement. Most patients carry the Z allele in SERPINA1 that encodes a mutant AAT (ATZ) forming hepatotoxic polymers. We found CHOP upregulation and activation in both mouse (PiZ) and human livers expressing ATZ. Compared to controls, juvenile PiZ/ Chop -/- mice showed reduction in hepatic ATZ and transcri...

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Literature Corpus work: dc3409e9-22dc-5567-b246-b41573e43967
DOI: 10.1101/2020.05.04.076752

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