Article

A phase 1 clinical trial of the repurposable acetyl-lysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

2022-09-29

Abstract excerpt

<h4>Background: </h4> N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and anti-myeloma properties that are partly explained by acetyllysine mimetic properties and non-specific bromodomain inhibition. We therefore evaluated or...

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Literature Corpus work: dbb568c9-72d2-53a6-9b0c-c8fe980cbd90
DOI: 10.21203/rs.3.rs-2102432/v1

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