Back to search

Article

Integrative Genomic Analysis Identifies the Soluble Receptor for Advanced Glycation End Products as Putatively Causal for Rheumatoid Arthritis

2020-07-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Identifying causal biomarkers of rheumatoid arthritis (RA) to improve treatment and monitor disease progression remains a critical but elusive goal. To search for putatively causal protein biomarkers of RA, we designed an integrative genomic strategy utilizing Mendelian randomization (MR), which allows for causal inference between an exposure and an outcome by incorporating ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
db1baa33-d8ca-5302-b88b-7162a6e39f03
DOI
10.1101/2020.07.01.20144352
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrative Genomic Analysis Identifies the Soluble Receptor for Advanced Glycation End Products as Putatively Causal for Rheumatoid ArthritisDOI 10.1101/2020.07.01.20144352
Integrative Mendelian randomization reveals the soluble receptor for advanced glycation end products as protective in relation to rheumatoid arthritis.Semantic proximity
The causal role of immune cells in rheumatoid arthritis: a Mendelian randomization studySemantic proximity
Integrative Analysis of Genetic, Proteomic, and Transcriptomic Data Reveals Novel Therapeutic Targets for Rheumatoid ArthritisSemantic proximity
Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study.Semantic proximity
Novel loci and multi-omics risk models for rheumatoid arthritis through a million-participant genome-wide association meta-analysisSemantic proximity
Plasma protein prioritisation in rheumatoid arthritis reveals druggable targets and shared biology with cardiovascular diseasesSemantic proximity
The Causal Relationship Between Genetically Determined Plasma Metabolites and Rheumatoid Arthritis.Semantic proximity
Serum biochemical markers and rheumatoid arthritis: Insights from observational study and Mendelian randomization analysisSemantic proximity
Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis.Semantic proximity
Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomisationSemantic proximity
Integrative Multiomics Network Analysis of Genetic Risk Factors to Infer Biomarkers and Therapeutic Targets for Rheumatoid ArthritisSemantic proximity
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.Semantic proximity
Select a neighboring publication to make it the new centre.