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Reduced Placental 11 -Hydroxysteroid Dehydrogenase Type 2 mRNA Levels in Human Pregnancies Complicated by Intrauterine Growth Restriction: An Analysis of Possible Mechanisms

2001-10-01

Abstract excerpt

11 beta -Hydroxysteroid dehydrogenase type 2 (11 beta -HSD2) inactivates cortisol to cortisone. In the placenta 11 beta -HSD2 activity is thought to protect the fetus from the deleterious effects of maternal glucocorticoids. Patients with apparent mineralocorticoid excess owing to mutations in the 11 beta -HSD2 gene invariably have reduced birth weight, and we have recently shown reduced placental 11 beta -HSD2 ac...

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Literature Corpus work: da777e16-f843-5044-a671-9e464477adfd
DOI: 10.1210/jc.86.10.4979

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