Article

Extent of damage to descending output from cortex rather than to specific cortical regions drives the emergence of flexor synergy in non-human primates

2026-03-06

Abstract excerpt

Obligate flexor synergies are a defining feature of the hemiparetic phenotype following stroke in humans. Although these intrusive synergies can diminish over time, recovery may plateau, leaving some individuals with movements permanently constrained to synergies. Despite their clinical significance, the neural mechanisms underlying the emergence and persistence of abnormal synergies remain poorly understood. To i...

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Literature Corpus work: da699963-0c9c-58ea-8353-d0d28e12f17b
DOI: 10.64898/2026.03.04.709517

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