Article

ALKBH5 enhances efficiency of anti-PD-1/PD-L1 therapy by reducing Lnc-XIST/miRNA- 124-3p mediated FGL1 expression in bladder cancer

2022-10-11

Abstract excerpt

<h4>Background: </h4> Fibrinogen-like 1 (FGL1), the promising inhibitory immune checkpoint, has been proved to promote immune escape and abrogate the efficacy of immunotherapy in malignancy. However, knowledge on its dynamic expression and regulatory mechanism in course of cancer immunotherapy is limited in bladder cancer (BCa). The vital roles of N6‑methyladenosine (m6A) RNA methylation have been identified in mu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da260759-e3e1-515d-9b54-d1ea76dd2168
DOI: 10.21203/rs.3.rs-2137267/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ALKBH5 enhances efficiency of anti-PD-1/PD-L1 therapy by reducing Lnc-XIST/miRNA- 124-3p mediated FGL1 expression in bladder cancerDOI 10.21203/rs.3.rs-2137267/v1Read

FAM111B, LAG3, and FGL1, A Three-Gene Signature as a Predictive Biomarker for Immunotherapy Response in Bladder Urothelial CarcinomaSemantic proximity Read

Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1–FGL1–MYH9 axisSemantic proximity Read

Identification of a FLG-wide-type bladder cancer subtype with poor prognosis and prediction use in immune checkpointSemantic proximity Read

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeSemantic proximity Read

IGHA1 and IGHG1 expression panel predicts anti-PD-L1 response in muscle-invasive bladder cancerSemantic proximity Read

Identification of SNHG16 and Its Derived Tumor Immune Gene Signatures for Predicting Prognosis and Efficacy of Immunotherapy in Bladder CancerSemantic proximity Read

Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascadeSemantic proximity Read

NEAT1/MALAT1/XIST/PKD--Hsa-Mir-101-3p--DLGAP5 Axis as a Novel Diagnostic and Prognostic Biomarker Associated With Immune Cell Infiltration in Bladder CancerSemantic proximity Read

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeSemantic proximity Read

Identification and Validation of N6-methyladenosine-related Biomarkers for Bladder Cancer: Implications for ImmunotherapySemantic proximity Read

M5C modulator mediated methylation pattern and TME cell infiltration in bladder cancerSemantic proximity Read

Pan-cancer Analysis Identifies LMNB1 as a Target to Redress Th1/Th2 Imbalance and Enhance PARP Inhibitor Response in Human CancersSemantic proximity Read