NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.

doi:10.1172/jci.insight.177152

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Article

NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.

JCI insight - 18 Jul 2024

Perry Caroline E, Halawani Sarah M, Mukherjee Sarmistha, Ngaba Lucie V, Lieu Melissa, Lee Won Dong, Davis James G, Adzika Gabriel K, Bebenek Alyssa N, Bazianos Daniel D, Chen Beishan, Mercado-Ayon Elizabeth, Flatley Liam P, Suryawanshi Arjun P, Ho Isabelle, Rabinowitz Joshua D, Serai Suraj D, Biko David M, Tamaroff Jaclyn, DeDio Anna, Wade Kristin, Lin Kimberly Y, Livingston David J, McCormack Shana E, Lynch David R, Baur Joseph A

Abstract excerpt

Friedreich's ataxia (FRDA) is a progressive disorder caused by insufficient expression of frataxin, which plays a critical role in assembly of iron-sulfur centers in mitochondria. Individuals are cognitively normal but display a loss of motor coordination and cardiac abnormalities. Many ultimately develop heart failure. Administration of nicotinamide adenine dinucleotide-positive (NAD+) precursors has shown...

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Identifiers

PMID: 39171530
DOI: 10.1172/jci.insight.177152
PMCID: PMC11343603

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