Article

Age-Related Changes in the Cholinergic System in Adults with Down Syndrome Assessed Using [<sup>18</sup>F]-Fluoroethoxybenzovesamicol Positron Emission Tomography Imaging

2024-11-01

Abstract excerpt

Adults with Down syndrome are genetically predisposed to developing Alzheimer’s disease after the age of 40. The cholinergic system, which is critical for cognitive functioning, is known to decline in Alzheimer’s disease and although first investigated in individuals with Down syndrome 40 years ago, remains relatively understudied. Existing studies suggest individuals with Down syndrome have an intact cholinergic...

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Literature Corpus work: d94a8a2d-f84a-50f0-a999-7ac21225d5ac
DOI: 10.1101/2024.10.28.24316136

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