Article

GALA: A Unified Landmark-Free Framework for Coarse-to-Fine Spatial Alignment Across Resolutions and Modalities in Spatial Transcriptomics

2025-12-02

Abstract excerpt

Spatial transcriptomics alignment is challenged by technical variations, including geometric distortions from tissue preparation and platform-driven differences in resolution and modality. These issues create diverse alignment scenarios, from matched and mismatched resolutions to cross-modality integration, while partial tissue coverage further complicates the task. To overcome these limitations, we introduce GALA...

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Literature Corpus work: d8b0dff9-1d6b-52cc-a07f-6077f33613c5
DOI: 10.64898/2025.11.29.691288

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