STR-PG: A Topology-decoupled Pangenome Framework for Scalable Short-read Genotyping of Short Tandem Repeats

Abstract excerpt

Short tandem repeats (STRs) are a rich and highly polymorphic source of human genetic variation, but representing and genotyping them in pangenome graphs remains challenging. Explicitly encoding each STR allele as a separate graph path results in increasingly complex local structures as cohort diversity increases, leading to larger index sizes and requiring significant resources for graph reconstruction when new a...

Topics

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• Algorithms
• Computer Graphics
• Genome, Human
• Genotyping Techniques
• High-Throughput Nucleotide Sequencing
• HLA Antigens
• Sequence Alignment
• Software

Identifiers and source

Literature Corpus work

d8967bf9-6ae5-54eb-8d0d-4d3872980d50

DOI

10.64898/2026.08.07.743532