Back to search

Article

In Silico Design of Multi-Target Compound Combinations against Alzheimer's Disease

2025-08-05

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with complex pathophysiology involving multiple targets such as amyloid beta (Aβ) and tau proteins. Current single-target drugs offer limited therapeutic benefits, highlighting the urgent need for a multi-target approach. This study aims to design and evaluate multi-target compound combinations (MTCCs) using in silico methods, focusing on six nat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d7edc0f7-bace-5948-8d2b-6b369f3ba54d
DOI
10.20944/preprints202508.0308.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
In Silico Design of Multi-Target Compound Combinations against Alzheimer's DiseaseDOI 10.20944/preprints202508.0308.v1
Targeting PD-1/PD-L1-MAPK1 Signaling by a Novel Synergistic Combination of Rivastigmine and Epigallocatechin in Alzheimer’s Disease: An Integrated Insilico ApproachSemantic proximity
Network Pharmacology-guided Identification and Molecular Validation of Multi-Target Phytoconstituents from Gmelina arborea against Alzheimer’s DiseaseSemantic proximity
Network Pharmacology-guided Identification and Molecular Validation of Multi-Target Phytoconstituents from Gmelina arborea against Alzheimer’s DiseaseSemantic proximity
Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's diseaseSemantic proximity
High-Throughput Screening and Molecular Dynamics Simulation of Natural Product-like Compounds against Alzheimer’s Disease through Multitarget ApproachSemantic proximity
Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s DiseaseSemantic proximity
African Natural Products for Multitarget-Based Treatment of Alzheimer’s Disease: An In Silico StudySemantic proximity
A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer diseaseSemantic proximity
Synergistic Approaches in Neurodegenerative Therapeutics: Multi-Target Drug Innovative Interventions for Alzheimer’s DiseaseSemantic proximity
Polyphenols in the Pipeline: Network-Based Docking, Molecular Dynamics and ADMET Studies of Flavonoids against Alzheimer’s diseaseSemantic proximity
Therapeutic Options in Alzheimer’s Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic ActivitySemantic proximity
Curcumin in Alzheimer’s Disease: From Mechanistic Insights to Translational Challenges and Emerging Curcuminoid StrategiesSemantic proximity
Select a neighboring publication to make it the new centre.