Article

Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression - the PRIME-PRAXOL randomized controlled trial

2025-10-29

Abstract excerpt

<title>Abstract</title> <p>Here, we examined the efficacy and target engagement of dopamine agonist pramipexole in treating a cross-diagnostic sample of mood disorders characterized by severe anhedonia. Patients with major depressive disorder, dysthymia or bipolar depression, all with significant anhedonia symptoms per the Snaith-Hamilton Pleasure Scale (SHAPS), were randomized to either a flexible-dose add-on of...

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Literature Corpus work: d7a8886e-d2f8-5cc9-ad0e-e2df003c7bdc
DOI: 10.21203/rs.3.rs-7887410/v1

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