Article

High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing

2023-05-04

Abstract excerpt

Abstract Autologous cellular therapies have been highly successful in treating hematological cancers and have the potential to be used for a variety of indications. Manufacturing these therapies rapidly and at low cost remains a major challenge. A key bottleneck in cellular therapy manufacturing is genetic modification of target cells, which is often done using viral vectors. Because vectors are expensive to devel...

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Literature Corpus work: d6fe2efb-b621-58d5-b274-86b0695f9cde
DOI: 10.1002/admt.202300275

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