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MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

2020-10-26

Abstract excerpt

<h4>Background: </h4> In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell lymphoma (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment remodeling account for FL progression. A panel of microRNA (miRNA) was downregulated in transformed FL. <h4>Methods: </h4>: Differentially expressed miRNAs were systemati...

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Literature Corpus work
d6dd8f61-b19b-5c18-8943-7e2e402d9afa
DOI
10.21203/rs.3.rs-38701/v3
Open publication

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MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophagesDOI 10.21203/rs.3.rs-38701/v3
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