Article

Melatonin Sensitize the Ovarian Cancer Cells to Cisplatin through suppression of PI3K/Akt pathway

2021-05-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The present study elucidated the effect of melatonin on oxidative stress status, the expression of pro-apoptotic protein (caspase 3 and cleaved caspase 3), anti-apoptotic proteins (X-linked apoptosis inhibitor protein (XIAP) and Survivin), and the activity of PI3K/Akt signaling pathway in human ovarian cancer cell line.<bold>Methods:</bold> Human ovarian cancer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6ac9d0a-d17b-5f95-8cd3-4318ab6aa1b3
DOI: 10.21203/rs.3.rs-497936/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Melatonin Sensitize the Ovarian Cancer Cells to Cisplatin through suppression of PI3K/Akt pathwayDOI 10.21203/rs.3.rs-497936/v1Read

The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancerSemantic proximity Read

Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitroSemantic proximity Read

PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cellsSemantic proximity Read

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic StrategiesSemantic proximity Read

Akt-Mediated Cisplatin Resistance in Ovarian Cancer: Modulation of p53 Action on Caspase-Dependent Mitochondrial Death PathwaySemantic proximity Read

SHCBP1 promotes cisplatin resistance of ovarian cancer through AKT/mTOR/Autophagy pathwaySemantic proximity Read

Synergistic actions of Alpelisib and Melatonin in breast cancer cell lines with PIK3CA gene mutation.Semantic proximity Read

Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer CellsSemantic proximity Read

Different Cytotoxic Effects of Cisplatin on Pancreatic Ductal Adenocarcinoma Cell LinesSemantic proximity Read

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancerSemantic proximity Read

Apoptosis Induced by Melatonin and Vitamin D3 in MCF-7 Breast Cancer Cell Line by Upregulating the Gene Expression of P53Semantic proximity Read

Apigenin-Melatonin: a novel prostate cancer Radiation SensitizerSemantic proximity Read