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Article

Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro

18 Sept 2012

Abstract excerpt

Platinum resistance is the most crucial problem for treatment of ovarian cancer. Increasing evidence points towards AKT overexpression as a mechanistic reason for this clinical condition. The present study evaluates the effect of overexpression and downregulation of AKT on the sensitivity to cisplatin in a platinum-resistant human ovarian cancer cell line and the corresponding platinum-sensitive parental cell...

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Identifiers

PMID: 22992944
DOI: 10.3892/or.2012.2041

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