Article

A k-mer-based estimator of the substitution rate between repetitive sequences

2025-06-25

Abstract excerpt

K-mer-based analysis of genomic data is ubiquitous, but the presence of repetitive k-mers continues to pose problems for the accuracy of many methods. For example, the Mash tool (Ondov et al 2016) can accurately estimate the substitution rate between two low-repetitive sequences from their k-mer sketches; however, it is inaccurate on repetitive sequences such as the centromere of a human chromosome. Follow-up work...

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Literature Corpus work: d69f4831-ff45-5b4d-9760-dc7fe775d8f9
DOI: 10.1101/2025.06.19.660607

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