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A humanized <i>Caenorhabditis elegans</i> model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4

2023-01-08

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a group of degenerative neurological disorders. We identified a variant in human kinesin light chain KLC4 that is suspected to be associated with autosomal dominant HSP. How this and other variants relate to pathologies is unknown. We created a humanized C. elegans model where klc- 2 was replaced with human KLC4 and assessed the extent to which hKLC4 retained function in...

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Literature Corpus work
d69b9e73-455d-5c93-b4b9-8bf7d4f4a715
DOI
10.1101/2023.01.07.523106
Open publication

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A humanized <i>Caenorhabditis elegans</i> model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4DOI 10.1101/2023.01.07.523106
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