Article

Dementia Entanglements in a Postgenomic Era

2010-11-17

Abstract excerpt

As genetic tests become cheaper and more readily available, pressure is increasing to routinely test individuals for susceptibility genes for complex common disorders. Using Alzheimer’s disease (AD) as an illustrative example, it is shown how population databases of AD cases on which individual risk estimates are based are faulty due to confusion about the AD phenotype. Furthermore, the APOEe4 genotype associated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d66097f4-bed9-5dde-85a1-091b34f36777
DOI: 10.1177/0162243910388022

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Dementia Entanglements in a Postgenomic EraDOI 10.1177/0162243910388022Read

A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease.Semantic proximity Read

Susceptibility genes and the question of embodied identity.Semantic proximity Read

Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg.Semantic proximity Read

When it runs in the family: putting susceptibility genes in perspectiveSemantic proximity Read

Genetic testing and Alzheimer disease: recommendations of the Stanford Program in Genomics, Ethics, and Society.Semantic proximity Read

Tracing Alzheimer’s Genetic Footprints: A Pioneering Longitudinal Study Using Artificial Intelligence to Unravel Mutation- Driven Risks and Progression in Virtual Patients; Part 1 – The APOE genotypesSemantic proximity Read

Postgenomics, uncertain futures, and the familiarization of susceptibility genes.Semantic proximity Read

Tracing Alzheimer's Genetic Footprints: A Pioneering Longitudinal Study Using Artificial Intelligence to Unravel Mutation-Driven Risks and Progression in Virtual Patients; Part 2 – The APP, PSEN1 and PSEN2 mutationsSemantic proximity Read

Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences.Semantic proximity Read

Epigenetics of dementia: understanding the disease as a transformation rather than a stateSemantic proximity Read

Presymptomatic apolipoprotein E genotyping for Alzheimer's disease risk assessment and prevention.Semantic proximity Read