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Integrated machine learning, single-cell RNA sequencing, and experimental validation to reveal the mechanisms of Fructus Aurantii in treating major depressive disorder

2026-06-09

Abstract excerpt

<title>Abstract</title> <p>Background Fructus Aurantii (FA), a Chinese herbal medicine, has been indicated to have antidepressant effects in our previous study. The potential mechanism of FA in the therapy of major depressive disorder (MDD) was explored through machine learning, single-cell RNA sequencing (scRNA-seq), and experimental validation. Methods We conducted differential analysis and WGCNA on the expre...

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Literature Corpus work: d5eb0773-9ad8-5242-8d3f-935f1f322ad5
DOI: 10.21203/rs.3.rs-9275696/v1

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