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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

2019-12-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP) are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who receive a proteasome inhibitor-containing regime for example, show cardiotoxicity. Moreover, UPS and ALP defects are implicated in the...

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Literature Corpus work
d5cb5409-2ea4-5a1b-a20c-500708e8d664
DOI
10.1101/2019.12.27.889519
Open publication

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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal MalfunctionDOI 10.1101/2019.12.27.889519
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