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Article

Establishment of variant free-iPSC (UOMi003-A) line from patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes.

Stem cell research - 1 Oct 2020

Sequiera Glen Lester, Rockman-Greenberg Cheryl, Dhingra Sanjiv

Abstract excerpt

Heteroplasmy in patients affected with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) offers a chance to harvest specific cells which might have a very low or no mutation load of the mitochondrial DNA. Here we demonstrate establishment of induced pluripotent stem cells (iPSC) cell lines (with normal mitochondrial DNA copies), from unaffected tissues of a male patient with MELAS...

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Identifiers

PMID: 32777772
DOI: 10.1016/j.scr.2020.101935

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