Discovery of highly potent pancoronavirus fusion inhibitors that also effectively inhibit COVID-19 variants from the UK (Alpha), South Africa (Beta), and India (Delta)

Abstract excerpt

<h4>ABSTRACT</h4> We report here the discovery of several highly potent small molecules that showed low nM potency against SARS-CoV (IC 50 : as low as 13 nM), SARS-CoV-2 (IC 50 : as low as 23 nM), and MERS-CoV (IC 50 : as low as 76 nM) in pseudovirus based assays with excellent selectivity indices (SI: as high as > 5000) demonstrating their pancoronavirus inhibition. Some compounds also show 100% inhibition of...

Topics

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• Computational Drug Discovery Methods
• COVID-19 Clinical Research Studies
• COVID-19 Impact on Reproduction
• Pharmacological Receptor Mechanisms and Effects
• SARS-CoV-2 and COVID-19 Research
• vaccines and immunoinformatics approaches
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

d51df67d-bcc9-5396-89d7-1847fff5200b

DOI

10.1101/2021.09.03.458877