Article

Characterization of the ligand binding pocket of the virulence regulator Rns, a Member of the AraC/XylS family of transcription factors

2025-01-14

Abstract excerpt

Diarrheal disease caused by Gram-negative enteric pathogens such as enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae , Shigella spp. , and, Salmonella spp. are a leading cause of morbidity and mortality of children; especially, in low resource nations. While progress has been made in reducing this burden, there remains a need to develop efficacious therapies. Recently, we determined the structure of R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4e57aef-ded7-57b0-9ec7-e8ebf21685a3
DOI: 10.1101/2025.01.14.633009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of the ligand binding pocket of the virulence regulator Rns, a Member of the AraC/XylS family of transcription factorsDOI 10.1101/2025.01.14.633009Read

Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric PathogensSemantic proximity Read

Horizontally acquired HosA transcription factor bound with 4-hydroxy-benzoic acid exhibits unique tug-of-water dynamicsSemantic proximity Read

Shigella flexneri utilizes intestinal signals to control its virulenceSemantic proximity Read

Site-specific acylation of a bacterial virulence regulator attenuates infection.Semantic proximity Read

Deciphering the acylation pattern of Yersinia enterocolitica lipid A.Semantic proximity Read

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to OmicronSemantic proximity Read

Reverse engineering of an aspirin-responsive regulator in bacteriaSemantic proximity Read

Residues near the amino terminus of Rns are essential for positive autoregulation and DNA binding.Semantic proximity Read

A 4-Hydroxybenzoic Acid-Mediated Signaling System Controls the Physiology and Virulence of Shigella sonneiSemantic proximity Read

Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter.Semantic proximity Read

Computational exploration of natural compounds targeting Staphylococcus aureus : inhibiting AgrA promoter binding for antimicrobial interventionSemantic proximity Read

In silico and in vitro studies of cinnamaldehyde and their derivatives against LuxS in Streptococcus pyogenes: effects on biofilm and virulence genesSemantic proximity Read