Article
Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype
2018-09-28
Abstract excerpt
In observational studies, the Mendelian randomization approach can be used to circumvent confounding, bias and reverse causation, and to assess a potential causal association between a biomarker and risk of disease. If, on the other hand, a substantial component of variance of a non-causal biomarker is explained by genotype, then genotype could potentially attenuate the observational association and the strength o...
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Identifiers and source
- Literature Corpus work
- d46ec1ef-5bd1-5b45-b6b3-312eaf464e41
- DOI
- 10.1101/428276