Article

RFC4 Drives Temozolomide Resistance in Glioblastoma by Activating STK38-BECN1-Dependent Autophagy

2025-06-24

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) remains intractable owing to treatment resistance and near-inevitable relapse. While autophagy has been demonstrated to contribute to temozolomide (TMZ) resistance, its regulatory mechanisms remain unclear. RFC4, a replication factor implicated in tumor progression, has not yet been systematically investigated in glioma for its potential role in autophagy regulation....

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Literature Corpus work: d3f37670-8a1f-5062-a6f4-a927cd089a87
DOI: 10.21203/rs.3.rs-6854944/v1

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