TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma

Abstract excerpt

BACKGROUND: Temozolomide (TMZ) resistance remains the main therapy challenge in patients with glioblastoma multiforme (GBM). TTK Protein Kinase (TTK) contributes to the radioresistance and chemoresistance in many malignancies. However, the role of TTK in the TMZ resistance of GBM cells remains unknown. METHODS: The expression of TTK was measured by western blot. The proliferation of GBM cells was assessed through...

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