Article

Ancestral intronic splicing regulatory elements in the SCNα gene family

2025-08-18

Abstract excerpt

SCNα genes encode components of voltage-gated sodium channels that are crucial for generating electrical signals. Humans have ten paralogous SCNα genes, some of which contain duplicated mutually exclusive exons 5a and 5b. In reconstructing their evolutionary history, we found multiple unannotated copies of exon 5 in distant species and showed that exon 5 duplication goes back to a common ancestor of the SCNα gene...

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Literature Corpus work: d3bf24af-7999-5a49-9329-2eb29ad5afb3
DOI: 10.1101/2025.08.16.670673

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