Article

Chronic early-life obesity linked to childhood impulsivity predicts long-term psychosis trajectory through dose-dependent cerebellar dysmaturation in 22q11.2 Deletion Syndrome

2025-02-14

Abstract excerpt

<h4>Background</h4> Recent epidemiological evidence links early-life obesity and metabolic dysregulation to adult psychosis vulnerability, though a causal relationship remains unclear. Establishing causality in highly heritable psychotic disorders requires: 1) demonstrating that early-life metabolic factors mediate between genetic vulnerability and psychosis trajectory, 2) dissecting mechanisms leading to early-li...

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Literature Corpus work: d3b5002d-a465-558b-a5be-4e5b89aa094b
DOI: 10.1101/2025.02.13.25322209

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