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Low Dose Radiation by Radiopharmaceutical Therapy Enhances GD2 <i>TRAC-</i> CAR T Cells Efficacy in Localized Neuroblastoma

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> While chimeric antigen receptor (CAR) T cells have achieved significant success against hematological malignancies, efficacy against neuroblastoma has been limited. Virus-free CRISPR-edited GD2 TRAC- CAR T cells have been developed as a potential means of improving CAR T efficacy but are not curative. Radiopharmaceutical therapy (RPT) is a promising approach to enhance the...

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Literature Corpus work
d3ad3557-07e4-5547-84ba-8bb5ee4fa9fa
DOI
10.1101/2024.11.02.621668
Open publication

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