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Stable <i>DNMT3L</i> Overexpression in SH-SY5Y Neurons Recreates a Facet of the Genome-Wide Down Syndrome DNA Methylation Signature

2020-11-09

Abstract excerpt

Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain. The molecular mechanisms involve the overexpression of genes related to DNA methylation on chromosome 21. Here, we stably overexpressed the chromosome 21 gene DNA methyltransferase 3L ( DNMT3L ) in the human SH-SY5Y neuroblastoma cell line and assay...

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Literature Corpus work: d34f43f9-231a-526f-838e-e08b30727626
DOI: 10.1101/2020.11.09.374793

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Stable <i>DNMT3L</i> Overexpression in SH-SY5Y Neurons Recreates a Facet of the Genome-Wide Down Syndrome DNA Methylation SignatureDOI 10.1101/2020.11.09.374793Read

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