Article

Myogenic dysregulation underlies tongue overgrowth in Beckwith-Wiedemann syndrome

2026-05-20

Abstract excerpt

<h4>Summary</h4> Macroglossia is a clinically significant feature of Beckwith-Wiedemann syndrome (BWS), but the cellular basis of tongue overgrowth remains poorly defined. Here, using pediatric tongue specimens from molecularly defined BWS subtypes and age-matched nonBWS controls, we show that BWS macroglossia is characterized by skeletal muscle fiber hypertrophy rather than increased fiber number. This phenotype...

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Literature Corpus work: d304c10f-8885-5aa8-8d29-eac878c91043
DOI: 10.64898/2026.05.18.725925

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