The Staphylococcus aureus non-coding RNA IsrR regulates TCA cycle activity and virulence.

doi:10.1093/nar/gkae1243

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Article

The Staphylococcus aureus non-coding RNA IsrR regulates TCA cycle activity and virulence.

Nucleic acids research - 8 Feb 2025

Rios-Delgado Gustavo, McReynolds Aubrey K G, Pagella Emma A, Norambuena Javiera, Briaud Paul, Zheng Vincent, Munneke Matthew J, Kim Jisun, Racine Hugo, Carroll Ronan K, Zelzion Ehud, Skaar Eric, Bose Jeffrey L, Parker Dane, Lalaouna David, Boyd Jeffrey M

Abstract excerpt

Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in host tissues. Staphylococcus aureus uses the ferric uptake transcriptional regulator (Fur) to sense titers of cytosolic Fe. Upon Fe depletion, apo-Fur relieves transcriptional repression of genes utilized for Fe uptake. We demonstrate that an S. aureus Δfur mutant has decreased expression of acnA, which codes for the...

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Topics

Staphylococcus aureus
Animals
Gene Expression Regulation, Bacterial
Citric Acid Cycle
Iron

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bacterial Proteins

Virulence

Mice

Aconitate Hydratase

RNA, Untranslated

Staphylococcal Infections

RNA, Bacterial

Mutation

Source

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Identifiers

PMID: 39704109
DOI: 10.1093/nar/gkae1243
PMCID: PMC11879123

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