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Pan-cancer circular genomics identifies intratumoral <i>Staphylococcus lugdunensis</i> as a metabolic driver in bladder cancer

2026-04-16

Abstract excerpt

<h4>SUMMARY</h4> Intratumoral microbiota play key roles in cancer but are challenging to profile due to low biomass. We developed CIRCMIP, an enzymatic pipeline that eliminates linear DNA to enrich bacterial genomes, achieving 100-fold higher sensitivity than standard metagenomics. Applied to 312 pan-cancer specimens, CIRCMIP identified Staphylococcus lugdunensis as a signature bacterium enriched in early-stage...

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Literature Corpus work
d2e66cd8-c6d1-538c-85aa-2a370f0df462
DOI
10.64898/2026.04.14.717102
Open publication

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