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Approaching an Error-Free Diploid Human Genome Using a Support-Based Validation Framework

2025-08-01

Abstract excerpt

Complete human genomes now resolve regions long inaccessible to genetic analysis, yet repetitive and structurally complex sequences remain prone to assembly errors because of limitations in current assembly algorithms. We introduce a support-based framework founded on the principle that each sequencing read provides independent evidence for the underlying genome sequence. Implemented through Sufficient Alignment S...

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Literature Corpus work
d289e8c2-51d1-5e1e-93f1-08a18a5e5eec
DOI
10.1101/2025.08.01.667781
Open publication

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Approaching an Error-Free Diploid Human Genome Using a Support-Based Validation FrameworkDOI 10.1101/2025.08.01.667781
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