Article

Prediction of Optimal Time of Day for Salmeterol Based on Circadian Phases of Target Proteins in the Target Tissues

2025-09-26

Abstract excerpt

Circadian rhythms are conserved across a wide range of organisms, including cyanobacteria, fungi, insects, and mammals. Approximately 50% of gene transcription, 8-38% of protein translation, and 13-22% of metabolites in mice have been shown to cycle with 24-hour rhythmicity. Approximately 75% of the current medications on the market target circadian-controlled pathways. However, current drug discovery and improvem...

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Literature Corpus work: d183ec82-adf3-5c91-bb4a-b7d2bbccf07e
DOI: 10.1101/2025.09.24.673459

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