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Article

Homozygous TNNI3 frameshift variant in a consanguineous family with lethal infantile dilated cardiomyopathy.

Molecular genetics & genomic medicine - 1 Jun 2024

Kraoua Lilia, Louati Assaad, Ahmed Sarra Ben, Abida Nesrine, Khemiri Monia, Menif Khaled, Mrad Ridha, Zaffran Stéphane, Jaouadi Hager

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle, systolic dysfunction, and normal or reduced thickness of the left ventricular wall. It is a leading cause of heart failure and cardiac death at a young age. Cases with neonatal onset DCM were correlated with severe clinical presentation and poor prognosis. A monogenic molecular etiology accounts for nearly half of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38924380
DOI: 10.1002/mgg3.2486
PMCID: PMC11196996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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