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Article

RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.

BMC gastroenterology - 10 Jan 2024

Lai Yuexing, Dong Hairong, Xu Ping, Wang Jing, Feng Wen, Zhao Zhenya, Sha Linyu

Abstract excerpt

BACKGROUND: The m6A modified demethylase FTO affects the progression of gastric cancer (GC), and the role mechanism of FTO in GC is still unclear. We, here, explored the role of FTO and unrevealed the mechanisms of its function in GC. METHODS: The expression and clinical prognosis of FTO in GC were examined via UALCAN and GEPIA online databases. Effect of FTO shRNA on GC cellular malignant phenotype were proved...

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Identifiers

PMID: 38200441
DOI: 10.1186/s12876-023-03065-y
PMCID: PMC10777655

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