Article

Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractions

2017-07-25

Abstract excerpt

Although critical for studies of gut motility and intestinal regeneration, the in vitro culture of intestinal muscularis with peristaltic function remains a significant challenge. Periodic contractions of intestinal muscularis result from the coordinated activity of smooth muscle cells (SMC), the enteric nervous system (ENS), and interstitial cells of Cajal (ICC). Reproducing this activity requires the preservati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf37f28f-fda4-5ecb-beed-cb2aaf919eba
DOI: 10.1101/152132

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractionsDOI 10.1101/152132Read

The Enteric Nervous System is Essential for Functional Muscle Layer Formation in Small Bowel BioengineeringSemantic proximity Read

A Centimeter-Scale, Peristaltic Human Intestinal Organoid with Integrated Neuro-Immune-Vascular Systems Recapitulates Enteritis and Orthotopic Colorectal CancerSemantic proximity Read

Building additional complexity to in vitro-derived intestinal tissuesSemantic proximity Read

Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small IntestineSemantic proximity Read

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.Semantic proximity Read

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculatureSemantic proximity Read

Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells.Semantic proximity Read

The Potential for Gut Organoid Derived Interstitial Cells of Cajal in Replacement Therapy.Semantic proximity Read

The gut brain in a dish: Murine primary enteric nervous system cell culturesSemantic proximity Read

Disruption of interstitial cells of Cajal networks after massive small bowel resection.Semantic proximity Read

Interstitial cells of Cajal at the clinical and scientific interface.Semantic proximity Read

In Vitro Models of the Small Intestine: Engineering Challenges and Engineering SolutionsSemantic proximity Read