Article

Preoperative prediction of microsatellite instability in rectal cancer using multiparametric MRIderived intratumoral heterogeneity and exploration of biological mechanisms: a multicenter study

2026-09-01

Abstract excerpt

<title>Abstract</title> <p>Objective To develop a multi-parametric MRI-based intratumoral heterogeneity (ITH) scoring model combined with clinical features for preoperative prediction of microsatellite instability (MSI) in rectal cancer, and to explore MSI-related molecular features. Methods A retrospective multicenter study of 464 rectal cancer patients (training n = 198, internal validation n = 110, external...

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Literature Corpus work: cf25f3f6-79b1-552d-a2d8-636f01108559
DOI: 10.21203/rs.3.rs-10721594/v1

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